Dostęp do tego artykułu jest płatny.
Zapraszamy do zakupu!
Po dokonaniu zakupu artykuł w postaci pliku PDF prześlemy bezpośrednio pod twój adres e-mail.
Biologiczne granice ruchu ortodontycznego – mechanobiologiczne determinanty bezpieczeństwa leczenia
Anna Ewa Kuc, Magdalena Sulewska, Grzegorz Hajduk, Joanna Lis, Beata Kawala, Michał Sarul
Streszczenie
Współczesne leczenie ortodontyczne wymaga uwzględnienia nie tylko celów estetycznych i okluzyjnych, ale także biologicznych ograniczeń kości wyrostka zębodołowego i tkanek przyzębia. Ten sam plan biomechaniczny może u jednego pacjenta prowadzić do kontrolowanego remodelingu, a u innego zwiększać ryzyko recesji dziąsłowych, dehiscencji, fenestracji lub resorpcji korzeni. W artykule omówiono najważniejsze czynniki decydujące o bezpieczeństwie ruchu ortodontycznego: gęstość i mikroarchitekturę kości, fenotyp przyzębia, wiek pacjenta, higienę jamy ustnej, stan zapalny tkanek brzeżnych, głębokość kortykotomii, charakter obciążeń mechanicznych oraz ryzyko kontaktu korzeni z blaszką korową i kanałem przysiecznym. Szczególną uwagę zwrócono na mechanobiologiczną interpretację ruchu zęba, w której znaczenie ma nie tylko wartość siły, ale także czas jej działania, lokalna perfuzja, hipoksja oraz odpowiedź immunologiczna tkanek. Przedstawiono również praktyczne „czerwone flagi”, które powinny skłaniać do bardziej ostrożnego planowania leczenia, wykonania CBCT lub konsultacji periodontologicznej. Artykuł podkreśla, że pytanie „czy można przesunąć ząb?” powinno zostać zastąpione pytaniem: „czy można przesunąć go bezpiecznie biologicznie?”.
Abstract
Modern orthodontic treatment requires consideration not only of esthetic and occlusal goals, but also of the biological limitations of the alveolar bone and periodontal tissues. The same biomechanical plan may result in controlled remodeling in one patient, while increasing the risk of gingival recession, dehiscence, fenestration, or root resorption in another. This article discusses the key factors determining the safety of orthodontic tooth movement, including bone density and microarchitecture, periodontal phenotype, patient age, oral hygiene, marginal tissue inflammation, corticotomy depth, mechanical loading pattern, and the risk of root proximity to the cortical plate or incisive canal. Particular attention is given to a mechanobiological interpretation of tooth movement, in which not only force magnitude but also force duration, local perfusion, hypoxia, and tissue immune response influence treatment outcomes. Practical “red flags” are also presented to help identify patients who may require more cautious treatment planning, CBCT evaluation, or periodontal consultation. The article emphasizes that the clinical question should shift from “Can the tooth be moved?” to “Can the tooth be moved safely from a biological perspective?”
PIŚMIENNICTWO
1. Krishnan V, Davidovitch Z. On a path to unfolding the biological mechanisms of orthodontic tooth movement. J Dent Res. 2009 Jul;88(7):597-608. doi: 10.1177/0022034509338914. PMID: 19641146.
2. Wang L, You X, Zhang L, Zhang C, Zou W. Mechanical regulation of bone remodeling. Bone Res. 2022 Feb 18;10(1):16. doi: 10.1038/s41413-022-00190-4. PMID: 35181672; PMCID: PMC8857305.
3. Kuc AE, Kotuła J, Nawrocki J, Kulgawczyk M, Kawala B, Lis J, Sarul M. Bone Remodeling of Maxilla after Retraction of Incisors during Orthodontic Treatment with Extraction of Premolars Based on CBCT Study: A Systematic Review. J Clin Med. 2024 Mar 5;13(5):1503. doi: 10.3390/jcm13051503. PMID: 38592367; PMCID: PMC10932275.
4. Kuc AE, Stankiewicz M, Kotuła J, Kuc N, Hajduk G, Małachowski J, Sarul M. The Influence of Bone Density on Stresses in the Periodontal Ligament During Orthodontic Movement—Finite Element Study on Innovative Model. Materials (Basel). 2025 Feb 10;18(4):776. doi: 10.3390/ma18040776. PMID: 40004301; PMCID: PMC11857563.
5. Wang J, Huang Y, Chen F, Li W. The age-related effects on orthodontic tooth movement and the surrounding periodontal environment. Front Physiol. 2024 Sep 6;15:1460168. doi: 10.3389/fphys.2024.1460168. PMID: 39308977; PMCID: PMC11412856.
6. Schubert A, Jäger F, Maltha JC, Bartzela TN. Age effect on orthodontic tooth movement rate and the composition of gingival crevicular fluid: a literature review. J Orofac Orthop. 2020 Mar;81(2):113-125. doi: 10.1007/s00056-019-00206-5. Epub 2020 Jan 9. PMID: 31919542.
7. Xu B, Yang K. Changes in alveolar bone structure during orthodontic tooth movement in adolescent and adult rats: a microcomputed tomography study. Orthod Craniofac Res. 2023 Nov;26(4):568-575. doi: 10.1111/ocr.12646. Epub 2023 Mar 10. PMID: 36866954.
8. Wise GE, King GJ. Mechanisms of tooth eruption and orthodontic tooth movement. J Dent Res. 2008 May;87(5):414-34. doi: 10.1177/154405910808700509. PMID: 18434571; PMCID: PMC2387248.
9. Yao S, Pan F, Prpic V, Wise GE. Differentiation of stem cells in the dental follicle. J Dent Res. 2008 Aug;87(8):767-71. doi: 10.1177/154405910808700801. PMID: 18650550; PMCID: PMC2553250.
10. Wise GE, Yao S, Zhang Q, Ren Y. Inhibition of osteoclastogenesis by the secretion of osteoprotegerin in vitro by rat dental follicle cells and its implications for tooth eruption. Arch Oral Biol. 2002 Mar;47(3):247-54. doi: 10.1016/S0003-9969(01)00109-1. PMID: 11839361.
11. Mori G, Ballini A, Carbone C, Oranger A, Brunetti G, Di Benedetto A, Rapone B, Cantore S, Di Comite M, Colucci S, Grano M, Grassi FR. Osteogenic differentiation of dental follicle stem cells. Int J Med Sci. 2012;9(6):480-7. doi: 10.7150/ijms.4583. Epub 2012 Aug 13. PMID: 22927773; PMCID: PMC3427952.
12. Wang CW, Yu SH, Mandelaris GA, Wang HL. Is periodontal phenotype modification therapy beneficial for patients receiving orthodontic treatment? An American Academy of Periodontology best evidence review. J Periodontol. 2020 Mar;91(3):299-310. doi: 10.1002/JPER.19-0037. Epub 2019 Nov 26. PMID: 31670836.
13. Zucchelli G, Mounssif I. Periodontal plastic surgery. Periodontol 2000. 2015 Jun;68(1):333-68. doi: 10.1111/prd.12059. PMID: 25867992.
14. Wennström JL. Mucogingival considerations in orthodontic treatment. Semin Orthod. 1996 Mar;2(1):46-54. doi: 10.1016/s1073-8746(96)80039-9. PMID: 9161283.
15. van Gastel J, Teughels W, Quirynen M, Struyf S, Van Damme J, Coucke W, Carels C. Longitudinal changes in gingival crevicular fluid after placement of fixed orthodontic appliances. Am J Orthod Dentofacial Orthop. 2011 Jun;139(6):735-44. doi: 10.1016/j.ajodo.2009.10.043. PMID: 21640879.
16. Ristic M, Vlahovic Svabic M, Sasic M, Zelic O. Clinical and microbiological effects of fixed orthodontic appliances on periodontal tissues in adolescents. Orthod Craniofac Res. 2007 Nov;10(4):187-95. doi: 10.1111/j.1601-6343.2007.00396.x. PMID: 17973685.
17. Marincak Vrankova Z, Rousi M, Cvanova M, Gachova D, Ruzicka F, Hola V, Lochman J, Izakovicova Holla L, Brysova A, Borilova Linhartova P. Effect of fixed orthodontic appliances on gingival status and oral microbiota: a pilot study. BMC Oral Health. 2022 Oct 27;22(1):455. doi: 10.1186/s12903-022-02511-9. PMID: 36303145; PMCID: PMC9615380.
18. Cerroni S, Pasquantonio G, Condò R, Cerroni L. Orthodontic Fixed Appliance and Periodontal Status: An Updated Systematic Review. Open Dent J. 2018 Sep 28;12:614-622. doi: 10.2174/1745017901814010614. PMID: 30369970; PMCID: PMC6182882.
19. Jati AS, Furquim LZ, Consolaro A. Gingival recession: its causes and types, and the importance of orthodontic treatment. Dental Press J Orthod. 2016 Jun;21(3):18-29. doi: 10.1590/2177-6709.21.3.018-029.oin. PMID: 27409650; PMCID: PMC4944726.
20. Kloukos D, Koukos G, Pandis N, Doulis I, Stavropoulos A, Katsaros C. Effect of orthodontic treatment with fixed appliances on the development of gingival recession. A prospective controlled study. Eur J Orthod. 2025 Apr 8;47(3):cjaf022. doi: 10.1093/ejo/cjaf022. PMID: 40432257; PMCID: PMC12116418.
21. Hassan AH, Al-Saeed SH, Al-Maghlouth BA, Bahammam MA, Linjawi AI, El-Bialy TH. Corticotomy-assisted orthodontic treatment. A systematic review of the biological basis and clinical effectiveness. Saudi Med J. 2015 Jul;36(7):794-801. doi: 10.15537/smj.2015.7.12437. PMID: 26108582; PMCID: PMC4503897.
22. Kuc AE, Kulgawczyk M, Sulewska ME, Kuc N, Kawala B, Lis J, Sarul M, Kotuła J. The Effect of Corticotomy-Assisted Orthodontic Therapy (CAOT) or Periodontally Accelerated Osteogenic Orthodontics (PAOO) on Bone Remodeling and the Health of Periodontium: A Systematic Review of Systematic Reviews. J Clin Med. 2024 Sep 26;13(19):5726. doi: 10.3390/jcm13195726. PMID: 39407786; PMCID: PMC11477216.
23. Kuc AE, Sybilski K, Kotuła J, Hajduk G, Sulewska M, Saternus S, Kulikowska-Kulesza JE, Kotarska M, Kawala B, Małachowski J, Sarul M. Corticotomy Depth as a Modulator of Orthodontic Tooth Movement and PDL Stress—A Finite Element Study. Materials (Basel). 2025 Nov 24;18(23):5290. doi: 10.3390/ma18235290. PMID: 41374132; PMCID: PMC12693079.
24. Kuc AE, Kotuła J, Sybilski K, Saternus S, Małachowski J, Kuc N, Hajduk G, Lis J, Kawala B, Sarul M, Sulewska M. Tension-Dominant Orthodontic Loading and Buccal Periodontal Phenotype Preservation: An Integrative Mechanobiological Model Supported by FEM and a Proof-of-Concept CBCT. J Funct Biomater. 2026 Jan 16;17(1):47. doi: 10.3390/jfb17010047. PMID: 41590815; PMCID: PMC12843214.
25. Kuc AE, Sulewska M, Sybilski K, et al. Mechanobiological Regulation of Alveolar Bone Remodeling: A Finite Element Study and Molecular Pathway Interpretation. Biomolecules. 2026;16(1):150.
26. Kirschneck C, Thuy M, Leikam A, Memmert S, Deschner J, Damanaki A, Spanier G, Proff P, Jantsch J, Schröder A. Role and Regulation of Mechanotransductive HIF-1α Stabilisation in Periodontal Ligament Fibroblasts. Int J Mol Sci. 2020 Dec 15;21(24):9530. doi: 10.3390/ijms21249530. PMID: 33333756; PMCID: PMC7765204.
27. Kirschneck C, Straßmair N, Cieplik F, Paddenberg E, Jantsch J, Proff P, Schröder A. Myeloid HIF1α Is Involved in the Extent of Orthodontically Induced Tooth Movement. Biomedicines. 2021 Jul 8;9(7):796. doi: 10.3390/biomedicines9070796. PMID: 34356859; PMCID: PMC8301336.
28. Niklas A, Proff P, Gosau M, Römer P. The role of hypoxia in orthodontic tooth movement. Int J Dent. 2013;2013:841840. doi: 10.1155/2013/841840. Epub 2013 Oct 21. PMID: 24228034; PMCID: PMC3818850.
29. Horiuchi A, Hotokezaka H, Kobayashi K. Correlation between cortical plate proximity and apical root resorption. Am J Orthod Dentofacial Orthop. 1998 Sep;114(3):311-8. doi: 10.1016/S0889-5406(98)70214-8. PMID: 9743137.
30. Nakada T, Motoyoshi M, Horinuki E, Shimizu N. Cone-beam computed tomography evaluation of the association of cortical plate proximity and apical root resorption after orthodontic treatment. J Oral Sci. 2016;58(2):231-6. doi: 10.2334/josnusd.15-0566. PMID: 27349544.
31. Mehta S, Chen PJ, Lin MH, Sharma G, Mehta F, Kuo CL, Tadinada A, Yadav S. Effect of the Proximity of Roots to the Cortical Plate and Inclination of Incisors on External Apical Root Resorption. Contemp Clin Dent. 2024 Jul-Sep;15(3):178-185. doi: 10.4103/ccd.ccd_454_23. Epub 2024 Sep 25. PMID: 39512293; PMCID: PMC11540203.
32. Kuc AE, Kotuła J, Nawrocki J, Babczyńska A, Lis J, Kawala B, Sarul M. The Assessment of the Rank of Torque Control during Incisor Retraction and Its Impact on the Resorption of Maxillary Central Incisor Roots According to Incisive Canal Anatomy—Systematic Review. J Clin Med. 2023 Apr 8;12(8):2774. doi: 10.3390/jcm12082774. PMID: 37109117; PMCID: PMC10144814.