Treatment of bone defects in root furcations. Part III. Tissue engineering – hope for the future

Bartłomiej Górski

Streszczenie

Regeneracja tkanek przyzębia (GTR) wymaga obecności komórek progenitorowych, przestrzeni dla rozwijających się tkanek i molekuł sygnalizujących, które regulują podziały mitotyczne i różnicowanie się komórek. Kluczowa wydaje się kontrola „wyścigu tkankowego”. Obecnie obserwuje się wzrost zainteresowania potencjalnym wykorzystaniem czynników wzrostu. Z inżynierią tkankową, która łączy ze sobą komórki, rusztowanie zewnątrzkomórkowe i molekuły sygnalizujące, wiążą się bardzo duże oczekiwania we wszystkich dziedzinach medycyny odtwórczej i stomatologii. Możliwe, że terapia z użyciem komórek macierzystych pozwoli w przyszłości przezwyciężyć niedogodności i „słabe strony” sterowanej regeneracji tkanek przyzębia.

Celem pracy jest przedstawienie współczesnej wiedzy i trendów w badaniach dotyczących czynników wzrostu i inżynierii tkankowej w szeroko rozumianym leczeniu periodontologicznym, a w szczególności w leczeniu zajętych furkacji korzeni.

Hasła indeksowe: ubytki w furkacjach korzeni, zapalenie przyzębia, czynniki wzrostu, osocze bogatopłytkowe, komórki progenitorowe

Summary

Regeneration of periodontal tissue (GTR) requires the presence of progenitor cells, space for the developing tissues and signalizing molecules that regulate mitotic divisions and cell differentiation. It appears that control of the “tissue race” is a key feature. At present interest in the potential use of growth factors can be observed. Great expectations in all aspects of restorative medicine and dentistry are awaited with tissue engineering which connects cells, extracellular scaffolding and signalizing molecules. It is possible that therapy using stem cells will in the future allow the overcoming of disadvantages and “weak aspects” of guided tissue regeneration of the periodontal tissues.

The aim of the study was to present contemporary trends in studies involving growth factors and tissue engineering in the widely understood concept of periodontal treatment, and, especially in the treatment of involved root furcations.

 

Key words: bony defects in root furcations, periodontal inflammation, growth factors, platelet rich plasma, progenitor cells

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