Dostęp do tego artykułu jest płatny.
Zapraszamy do zakupu!
Po dokonaniu zakupu artykuł w postaci pliku PDF prześlemy bezpośrednio pod twój adres e-mail.
Till Dammaschke
Streszczenie
Nawet w przypadku prawidłowego wypełnienia kanału korzeniowego, bez przepchnięcia materiału do tkanek przyzębia, składniki preparatów stosowanych w leczeniu endodontycznym mogą dyfundować do otaczających tkanek, a następnie rozprzestrzeniać się po organizmie za pośrednictwem naczyń krwionośnych i limfatycznych. Gutaperka i materiały uszczelniające powinny zatem charakteryzować się biozgodnością miejscową oraz brakiem niekorzystnego działania ogólnoustrojowego. W związku z tym należy wykluczyć stosowanie preparatów endodontycznych zawierających lub uwalniających formaldehyd ze względu na ich potencjał alergizujący oraz ryzyko toksyczności narządowej, genotoksyczności, mutagenności i neurotoksyczności. Krytycznej oceny wymaga również stosowanie tradycyjnych uszczelniaczy i cementów na bazie tlenku cynku i eugenolu. Warto też przyjrzeć się materiałom na bazie żywic epoksydowych ze względu na ich potencjał alergizujący i mutagenność w badaniach in vitro. Za najlepiej tolerowane uznaje się materiały bioceramiczne na bazie krzemianu wapnia. Odrębną grupę stanowią jednak materiały na bazie krzemianu wapnia modyfikowane żywicą, której obecność wymaga uwzględnienia potencjalnego działania toksycznego.
PIŚMIENNICTWO
- Geurtsen W, Leyhausen G. Biological aspects of root canal filling materials – histocompatibility, cytotoxicity, and mutagenicity. Clin Oral Investig. 1997; 1(1): 5-11.
- Huang TH, Lee H, Kao CT. Evaluation of the genotoxicity of zinc oxide eugenol-based, calcium hydroxide-based, and epoxy resin-based root canal sealers by comet assay. J Endod. 2001; 27(12): 744-748.
- Koppang HS, Koppang R, Stølen SØ. Identification of common foreign material in postendodontic granulomas and cysts. J Dent Assoc S Afr. 1992; 47(5): 210-216.
- Kerr AR, Miller CS, Rhodus NL i wsp. Little and Falace’s dental management of the medically compromised patient. 10th ed. St. Louis: Mosby; 2023.
- Herrmann H.W, Hülsmann M, Schäfer E. Probleme bei der Wurzelkanalfüllung. In: Probleme in der Endodontie. Prävention, Identifikation und Management. Hülsmann M, Schäfer E (Hrsg.). 2. Aufl. Berlin: Quintessenz; 2019: 291-322.
- Schäfer E. Allgemeinmedizinische Probleme. In: Probleme in der Endodontie. Prävention, Identifikation und Management. Hülsmann M, Schäfer E (Hrsg.). 2. Aufl. Berlin: Quintessenz; 2019: 71-100.
- Gazelius B, Olgart L, Wrangsjo K. Unexpected symptoms to root filling with gutta-percha. A case report. Int Endod J. 1986; 19(4): 202-204.
- Boxer MB, Grammer LC, Orfan N. Gutta-percha allergy in a health care worker with latex allergy. J Allergy Clin Immunol. 1994; 93(5): 943-944.
- Kang PB, Vogt K, Gruninger SE i wsp. The immuno cross-reactivity of gutta percha points. Dent Mater. 2007; 23(3): 380-384.
- Knowles KI, Ibarrola JL, Ludlow MO i wsp. Rubber latex allergy and the endodontic patient. J Endod. 1998; 24(11): 760-762.
- Hamann C, Rodgers PA, Alenius H i wsp. Cross-reactivity between gutta-percha and natural rubber latex: assumptions vs. reality. J Am Dent Assoc. 2002; 133(10): 1357-1367.
- Costa GE, Johnson JD, Hamilton RG. Cross-reactivity studies of gutta-percha, gutta-balata, and natural rubber latex (hevea brasiliensis). J Endod. 2001; 27(9): 584-587.
- Hook D, Fishelberg G. The use of gutta-percha for obturation during root canal therapy in latex-allergic patients. Gen Dent. 2003; 51(4): 337-339.
- Kleier DJ, Shibilski K. Management of the latex hypersensitive patient in the endodontic office. J Endod. 1999; 25(12): 825-828.
- Hellwig E, Schäfer E, Klimek J i wsp. Einführung in die Zahnerhaltung. Prüfungswissen Kariologie und Parodontologie. 8. Aufl., Köln: Deutscher Ärzteverlag; 2023.
- Karabucak B, Stoopler ET. Root canal treatment on a patient with zinc oxide allergy: a case report. Int Endod J. 2007; 40(10): 800-807.
- Burri ChR, Wüthrich B. Quincke-Ödem mit Urtikaria nach Zahnwurzelbehandlung mit einem Paraformaldehyd-haltigen Dentalantisepticum bei Spättyp-Sensibilisierung auf Paraformaldehyd. Allergologie. 1985; 8: 264-266.
- Forman GH, Ord RA. Allergic endodontic angio-oedema in response to periapical endomethasone. Br Dent J. 1986; 160(10): 348-350.
- Ebner H, Kraft D. Formaldehyde-induced anaphylaxis after dental treatment? Contact Dermatitis. 1991; 24(4): 307-309.
- Fehr BS, Huwyler T, Wüthrich B. Formaldehyd- und Paraformaldehyd-Allergie. Allergische Reaktionen auf Formaldehyd und Paraformaldehyd nach Zahnwurzelbehandlungen. Schweiz Monatsschr Zahnmed. 1992; 102(1): 94-97.
- Geusau A, Pirkhammer D, Aberer W. Anaphylaxie durch parafomaldehydehaltige Dentalmaterialen. Allergologie. 1994; 17(9): 439-441.
- el Sayed F, Seite-Bellezza D, Sans B i wsp. Contact urticaria from formaldehyde in a root-canal dental paste. Contact Dermatitis. 1995; 33(5): 353.
- Wantke F, Hemmer W, Haglmüller T i wsp. Anaphylaxis after dental treatment with a formaldehyde-containing tooth-filling material. Allergy. 1995; 50(3): 274-276.
- Haïkel Y, Braun JJ, Zana H i wsp. Anaphylactic shock during endodontic treatment due to allergy to formaldehyde in a root canal sealant. J Endod. 2000; 26(9): 529-531.
- Kunisada M, Adachi A, Asano H i wsp. Anaphylaxis due to formaldehyde released from root-canal disinfectant. Contact Dermatitis. 2002; 47(4): 215-218.
- Tas E, Pletscher M, Bircher AJ. IgE mediated urticaria from formaldehyde in a dental root canal compound. J Investig Allergol Clin Immunol. 2002; 12(2): 130-133.
- Braun JJ, Zana H, Purohit A i wsp. Anaphylactic reactions to formaldehyde in root canal sealant after endodontic treatment: four cases of anaphylactic shock and three of generalized urticaria. Allergy. 2003; 58(11): 1210-1215.
- Jang JH, Park SH, Jang HJ i wsp. A case of recurrent urticaria due to formaldehyde release from root-canal disinfectant. Yonsei Med J. 2017; 58(1): 252-254.
- Sarrami N, Pemberton MN, Thornhill MH i wsp. Adverse reactions associated with the use of eugenol in dentistry. Br Dent J. 2002; 193(5): 257-259.
- Barkin ME, Boyd JP, Cohen S. Acute allergic reaction to eugenol. Oral Surg Oral Med Oral Pathol. 1984; 57(4): 441-442.
- Bhalla M, Thami GP. Acute urticaria due to dental eugenol. 2003; 58(2): 158.
- Grade AC, Martens BP. Chronic urticaria due to dental eugenol. Dermatologica. 1989; 178(4): 217-220.
- Grade AC. Eugenol in wortelkanaalcement. Mogelijke oorzaak voor urticariële reacties. Ned Tijdschr Tandheelkd. 1995; 102(1): 9-11.
- McCarter RF. An unusual allergy. Midwest Dent. 1966; 42(4): 20.
- Hørsted P, Søholm B. Overfølsomhet over for rodfyldningsmaterialet AH26. Tandlægebladet. 1976; 80: 194-197.
- Hensten-Pettersen A, Ørstavik D, Wennberg A. Allergenic potential of root canal sealers. Endod Dent Traumatol. 1985; 1(2): 61-65.
- Hensten A, Jacobsen N. Allergic reactions in endodontic practice. Endodontic Topics. 2005; 12(1): 44-51.
- Koch MJ. Formaldehyde release from root canal sealers: influence of method. Int Endod J. 1999; 32(1): 10-16.
- Camargo CHR, Camargo SEA, Valera MC i wsp. The induction of cytotoxicity, oxidative stress, and genotoxicity by root canal sealers in mammalian cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009; 108(6): 952-960.
- Spångberg LSW, Barbosa SV, Lavigne GD. AH26 releases formaldehyde. J Endod. 1993; 19(12): 596-598.
- Schroeder A. Mitteilungen über die Abschlussdichtigkeit von Wurzelfüllmaterialien und erster Hinweis auf ein neuartiges Wurzelfüllmittel. Schweiz Monatsschr Zahnheilkd. 1954; 64(9): 921-931.
- Cohen BI, Pagnillo MK, Musikant BL i wsp. Formaldehyde from endodontic materials. Oral Health. 1998; 88(12): 37-39.
- Harndt R, Kaul A. Untersuchungen über den Verbleib des Bleies im Wurzelkanalfüllmaterial N2. Dtsch Zahnärztl Z. 1973; 28(5): 580-591.
- Oswald RJ, Cohn SA. Systemic distribution of lead from root canal fillings. J Endod. 1975; 1(2): 59-63.
- Chong R, Senzer J. Systemic distribution of 210PbO from root canal fillings. J Endod. 1976; 2(12): 381-384.
- Block RM, Lewis RD, Hirsch J i wsp. Systemic distribution of N2 paste containing 14C paraformaldehyde following root canal therapy in dogs. Oral Surg Oral Med Oral Pathol. 1980; 50(4): 350-560.
- Hata GI, Nishikawa I, Kawazoe S i wsp. Systemic distribution of 14C-labeled formaldehyde applied in the root canal following pulpectomy. J Endod. 1989; 15(11): 539-543.
- Araki K, Isaka H, Ishii T i wsp. Excretion of 14C‐formaldehyde distributed systemically through root canal following pulpectomy. Dent Traumatol. 1993; 9(5): 196-199.
- Lewis BB, Chestner SB. Formaldehyde in dentistry: a review of mutagenic and carcinogenic potential. J Am Dent Assoc. 1981; 103(3): 429-434.
- International Agency for Research on Cancer. Formaldehyde, 2-butoxyethanol and 1-tert-butoxypropan-2-ol. IARC Monogr Eval Carcinog Risks Hum. 2006; 88: 1-47.
- Economides N, Kotsaki-Kovatsi VP, Poulopoulos A i wsp. Experimental study of the biocompatibility of four root canal sealers and their influence on the zinc and calcium content of several tissues. J Endod. 1995; 21(3): 122-127.
- Kolokouris I, Kotsaki-Kovatsi VP, Economides N i wsp. Influence of zinc oxide and eugenol sealer on concentration of zinc, calcium and copper in rat tissues. Endod Dent Traumatol. 1998; 14(5): 210-213.
- Gencoglu N, Sener G, Omurtag GZ i wsp. Comparision of biocompatibility and cytotoxicity of two new root canal sealers. Acta Histochem. 2010; 112(6): 567-575.
- Aubeux D, Valot-Salengro A, Gautier G i wsp. Transforaminal and systemic diffusion of an active agent from a zinc oxide eugenol-based endodontic sealer containing hydrocortisone-in an in vivo model. Clin Oral Investig. 2020; 24(12): 4395-4402.
- Simsek N, Bulut ET, Ahmetoğlu F i wsp. Determination of trace elements in rat organs implanted with endodontic repair materials by ICP-MS. J Mater Sci: Mater Med. 2016; 27(3): 46.
- de Azevedo Queiroz ÍO, Machado T, Alves CC i wsp. Tracing the toxic ions of an endodontic tricalcium silicate-based sealer in local tissues and body organs. J Trace Elem Med Biol. 2021; 68: 126856.
- Delfino MM, de Abreu Jampani JL, Lopes CS i wsp. Comparison of Bio-C Pulpo and MTA Repair HP with White MTA: effect on liver parameters and evaluation of biocompatibility and bioactivity in rats. Int Endod J. 2021; 54(9): 1597-1613.
- Khalil WA, Eid NF. Biocompatibility of bioaggregate and mineral trioxide aggregate on the liver and kidney. Int Endod J. 2013; 46(8): 730-737.
- Garcia L da FR, Huck C, Magalhães FAC i wsp. Systemic effect of mineral aggregate-based cements: histopathological analysis in rats. J Appl Oral Sci. 2017; 25(6): 620-630.
- Schuster L, Dammaschke T. Resin-based calcium silicate cements. In: Calcium silicate-based materials in endodontics. Properties and clinical applications. Lipski M, Dammaschke T (eds.). Lublin: Czelej; 2026: 232-244.
- Bakir EP, Yildirim ZS, Bakir Ş i wsp. Are resin-containing pulp capping materials as reliable as traditional ones in terms of local and systemic biological effects? Dent Mater J. 2022; 41(1): 78-86.
- Marciano MA, Pelepenko LE, Francati TM i wsp. Bismuth release from endodontic materials: in vivo analysis using Wistar rats. Sci Rep. 2023; 13(1): 9738.
- Pelepenko LE, Hewitt B, de Oliveira RB i wsp. Bismuth release from endodontic materials: proposed mechanisms for systemic circulation and organ accumulation. J Hazard Mater. 2025; 494: 138580.
- Janini ACP, Moraes BF, Pelepenko LE i wsp. Physicochemical properties and biological interaction of calcium silicate-based sealers – in vivo model. Clin Oral Investig. 2025; 29(1): 86.
- Janini ACP, Pelepenko LE, Moraes BF i wsp. Chemical and in vivo analyses of calcium silicate-based materials in bone and connective tissues. Int Endod J. 2025; 58(3): 484-503.
- Schriever-Schwemmer G, Kreis P. Was ist Mutagenität/Genotoxizität? Arbeitsmedizin Sozialmedizin Umweltmedizin. 2020; 2: 77-81.
- Tai KW, Huang FM, Huang MS i wsp. Assessment of the genotoxicity of resin and zinc-oxide eugenol-based root canal sealers using an in vitro mammalian test system. J Biomed Mater Res. 2002; 59(1): 73-77.
- Ko H, Jeong Y, Kim M. Cytotoxicities and genotoxicities of cements based on calcium silicate and of dental formocresol. Mutat Res Toxicol Environ Mutagen. 2017; 815: 28-34.
- Myers DR, Shoaf HK, Dirksen TR i wsp. Distribution of 14C-formaldehyde after pulpotomy with formocresol. J Am Dent Assoc. 1978; 96(5): 805-813.
- Block RM, Lewis RD, Hirsch J i wsp. Systemic distribution of 14C-labeled Paraformaldehyde incorporated within Formocresol following pulpotomies in dogs. J Endod. 1983; 9(5): 176-189.
- Jeon MJ, Ko H, Shin SJ i wsp. Cytotoxicity and genotoxicity of various types of endodontic sealers in Chinese hamster ovary (CHO-K1) cells. Dent Mater J. 2023; 42(6): 774-779.
- Brzovic V, Miletic I, Zeljezic D i wsp. In vitro genotoxicity of root canal sealers. Int Endod J. 2009; 42(3): 253-263.
- Santos NCN, Ramos MESP, Ramos AFB i wsp. Evaluation of the genotoxicity and cytotoxicity of filling pastes used for pulp therapy on deciduous teeth using the micronucleus test on bone marrow from mice (Mus musculus). Mutagenesis. 2016; 31(5): 589-595.
- Bin CV, Valera MC, Camargo SE i wsp. Cytotoxicity and genotoxicity of root canal sealers based on mineral trioxide aggregate. J Endod. 2012; 38(4): 495-500.
- Candeiro GTM, Moura-Netto C, D’Almeida-Couto RS i wsp. Cytotoxicity, genotoxicity and antibacterial effectiveness of a bioceramic endodontic sealer. Int Endod J. 2016; 49(9): 858-864.
- Eldeniz AU, Shehata M, Högg C i wsp. DNA double-strand breaks caused by new and contemporary endodontic sealers. Int Endod J. 2016; 49(12): 1141-1151.
- Victoria-Escandell A, Ibanez Cabellos JS, Sanchez SB i wsp. Cellular responses in human dental pulp stem cells treated with three endodontic materials. Stem Cell Int. 2017; 2017: 8920356.
- Erdogan H, Yildirim S, Cobankara FK. Cytotoxicity and genotoxicity of salicylate- and calcium silicate-based root canal sealers on primer human periodontal ligament fibroblasts. Aust Endod J. 2021; 47(3): 645-653.
- Kim M, Hayashi M, Yu B i wsp. Cytotoxicity and genotoxicity of epoxy resin-based root canal sealers before and after setting procedures. Life (Basel). 2022; 12(6): 847.
- Malta CP, Musachio EAS, Fernandes EJ i wsp. Oxidative damage analysis and cell viability of Drosophila melanogaster exposed to three different endodontic sealers: an in vivo and ex vivo study. 2024; 112(4): 1178-1185.
- Tadin A, Badrov M, Juric Kacunic D i wsp. Evaluation of the genotoxicity and cytotoxicity of bioceramic endodontic sealers in HepG2 and V79 cell lines: an in vitro study using the comet and micronucleus assays. J Funct Biomater. 2025; 16(5): 169.
- Barcelos Só B, Martins MD, Reis Só MV i wsp. Genotoxicity and cytotoxicity comparison of calcium silicate-based and resin-based sealers on human periodontal ligament stem cells. Eur Endod J. 2022; 7(2): 129-134.
- van Landuyt KL, Geebelen B, Shehata M i wsp. No evidence for DNA double-strand breaks caused by endodontic sealers. J Endod. 2012; 38(5): 636-641.
- Silva GO, Cavalcanti BN, Oliveira TR i wsp. Cytotoxicity and genotoxicity of natural resin-based experimental endodontic sealers. Clin Oral Investig. 2016; 20(4): 815-819.
- Dhopavkar VV, Shivanand SS, Bhat K i wsp. Comparative evaluation of cytotoxic and genotoxic effects of three resin-based sealers by 3, (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and comet assay – an in vitro study. Contemp Clin Dent. 2021; 12(4): 376-382.
- Radwanski M, Rozpedek-Kaminska W, Galita G i wsp. Cytotoxicity and genotoxicity of bioceramic root canal sealers compared to conventional resin-based sealer. Sci Rep. 2024; 14(1): 4124.
- Schuster L, Dammaschke T. Resin-based calcium silicate sealers. In: Calcium silicate-based materials in endodontics – properties and clinical applications. Lipski M, Dammaschke T (eds.). Lublin: Czelej; 2026: 245-258.
- Darrag AM, Fayyad DM. Genotoxicity of three endodontic sealers by single cell gel-electrophoresis/comet assay. Tanta Dent J. 2014; 11(2): 85-92.
- Leme KSV, Salvadori DMF. In vitro toxicogenomic activity of an MTA/salicylate-based endodontic sealer. Toxicol Rep. 2022; 9: 1076-1081.
- Heil J, Reifferscheid G, Waldmann P i wsp. Genotoxicity of dental materials. Mutat Res. 1996; 368(3-4): 181-194.
- Martinho FC, Camargo SEA, Fernandes AMM i wsp. Comparison of cytotoxicity, genotoxicity and immunological inflammatory biomarker activity of several endodontic sealers against immortalized human pulp cells. Int Endod J. 2018; 51(1): 41-57.
- Camargo CH, Oliveira TR, Silva GO i wsp. Setting time affects in vitro biological properties of root canal sealers. J Endod. 2014; 40(4): 530-533.
- Donnermeyer D, Dammaschke T. Classification of hydraulic calcium silicate-based materials. In: Calcium silicate-based materials in endodontics – properties and clinical applications. Lipski M, Dammaschke T (eds.). Lublin: Czelej; 2026: 4-15.
- Ribeiro DA, Duarte MA, Matsumoto MA i wsp. Biocompatibility in vitro tests of mineral trioxide aggregate and regular and white Portland cements. J Endod. 2005; 31(8): 605-607.
- Ribeiro DA, Matsumoto MA, Duarte MA i wsp. In vitro biocompatibility tests of two commercial types of mineral trioxide aggregate. Braz Oral Res. 2005; 19(3): 183-187.
- Braz MG, Camargo EA, Salvadori DM i wsp. Evaluation of genetic damage in human peripheral lymphocytes exposed to mineral trioxide aggregate and Portland cements. J Oral Rehabil. 2006; 33(3): 234-239.
- Ribeiro DA, Matsumoto MA, Duarte MA i wsp. Ex vivo biocompatibility tests of regular and white forms of mineral trioxide aggregate. Int Endod J. 2006; 39(1): 26-30.
- Ribeiro DA, Sugui MM, Matsumoto MA i wsp. Genotoxicity and cytotoxicity of mineral trioxide aggregate and regular and white Portland cements on Chinese hamster ovary (CHO) cells in vitro. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(2): 258-261.
- da Silva GN, Braz MG, de Camargo EA i wsp. Genotoxicity in primary human peripheral lymphocytes after exposure to regular and white mineral trioxide aggregate. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 102(5): e50-e54.
- Camargo SEA, Camargo CHR, Hiller KA i wsp. Cytotoxicity and genotoxicity of pulp capping materials in two cell lines. Int Endod J. 2009; 42(3): 227-237.
- Ding SJ, Kao CT, Chen CL i wsp. Evaluation of human osteosarcoma cell line genotoxicity effects of mineral trixoide aggregate and calcium silicate cements. J Endod. 2010; 36(7): 1158-1162.
- Zeferino EG, Bueno CE, Oyama LM i wsp. Ex vivo assessment of genotoxicity and cytotoxicity in murine fibroblasts exposed to white MTA or white Portland cement with 15% bismuth oxide. Int Endod J. 2010; 43(10): 843-848.
- Fernández R, Berruecos C, Motta MCC i wsp. Genotoxicity and hemocompatibility of a novel calcium aluminate-based cement. Eur Endod J. 2018; 19(3): 87-92.
- Kunert M, Rozpedek-Kaminska W, Galita G i wsp. The cytotoxicity and genotoxicity of bioactive dental materials. Cells. 2022; 11(20): 3238.
- Esen M, Guven Y, Seyhan MF i wsp. Evaluation of the genotoxicity, cytotoxicity, and bioactivity of calcium silicate-based cements. BMC Oral Health. 2024; 24(1): 119.
- Gökdogan N, Ilgaz NS, Yılmaz MB i wsp. Cytotoxicity, DNA damage, and migration of SHEDs exposed to bioactive pulp capping materials: an in vitro study. BMC Oral Health. 2026; 26(1): 229.
- Nai GA, Logar G de A, Mori GG i wsp. Evaluation of the genotoxicity and mutagenicity of Ca3SiO5-based cement. Braz Oral Res. 2016; 30(1): e97.
- Abrão SMS, Gregorio D, Azevedo MKC i wsp. Cytotoxicity and genotoxicity of Bio-C Repair, Endosequence BC Root Repair, MTA Angelus and MTA Repair HP. Braz Dent J. 2023; 34(2): 14-20.
- Harti SA, Adarsha MS, Meena N i wsp. An in vitro assessment of cytotoxicity and genotoxicity of root repair materials. J Oral Maxillofac Pathol. 2023; 27(4): 700-705.
- Schweikl H, Schmalz G. Evaluation of the mutagenic potential of root canal sealers using the Salmonella/microsome assay. J Mater Sci: Mater Med. 1991; 2: 181-185.
- Stea S, Savarino L, Ciapetti G i wsp. Mutagenic potential of root canal sealers: evaluation through Ames testing. J Biomed Mater Res. 1994; 28(3): 319-328.
- Ersev H, Schmalz G, Bayirli G i wsp. Cytotoxic and mutagenic potencies of various root canal filling materials in eukaryotic and prokaryotic cells in vitro. J Endod. 1999; 25(5): 359-363.
- rstavik D, Hongslo JK. Mutagenicity of endodontic sealers. Biomaterials 1985; 6(2): 129-132.
- Kettering JD, Torabinejad M. Investigation of mutagenicity of mineral trioxide aggregate and other commonly used root-end filling materials. J Endod. 1995; 21(11): 537-542.
- Schweikl H, Schmalz G, Stimmelmayer H i wsp. Mutagenicity of AH26 in an in vitro mammalian cell mutation assay. J Endod. 1995; 21(8): 407-410.
- Jukić S, Miletić I, Anić I i wsp. The mutagenic potential of AH+ and AH26 by Salmonella/microsome assay. J Endod. 2000; 26(6): 321-324.
- Canter DA, Zeiger E, Haworth S i wsp. Comparative mutagenicity of aliphatic epoxides in Salmonella. Mutat Res. 1986; 172(2): 105-138.
- Schweikl H, Schmalz G, Federlin M. Mutagenicity of the root canal sealer AH Plus in the Ames test. Clin Oral Investig. 1998; 2(3): 125-129.
- Leyhausen G, Heil J, Reifferscheid G i wsp. Genotoxicity and cytotoxicity of the epoxy resin-based root canal sealer AH plus. J Endod. 1999; 25(2): 109-113.
- Laurent P, Camps J, De Méo M i wsp. Induction of specific cell responses to a Ca3SiO5-based posterior restorative material. Dent Mater. 2008; 24(11): 1486-1494.
- Grossman LI. Paresthesia from N2 or N2 substitute. Report of a case. Oral Surg Oral Med Oral Pathol. 1978; 45(1): 114-115.
- Brodin P, Røed A, Aars H i wsp. Neurotoxic effects of root filling materials on rat phrenic nerve in vitro. J Dent Res. 1982; 61(8): 1020-1023.
- Brodin P. Neurotoxic and analgesic effect of root canal cements and pulp-protecting dental materials. Endod Dent Traumatol. 1988; 4(1): 1-11.
- Tuğ Kılkış B, Er K, Taşdemir T i wsp. Neurotoxicity of various root canal sealers on rat sciatic nerve: an electrophysiologic and histopathologic study. Clin Oral Investig. 2015; 19(8): 2091-2100.
- Serper A, Uçer O, Onur R i wsp. Comparative neurotoxic effects of root canal filling materials on rat sciatic nerve. J Endod. 1998; 24(9): 592-594.
- Boiesen J, Brodin P. Neurotoxic effect of two root canal sealers with calcium hydroxide on rat phrenic nerve in vitro. Endod Dent Traumatol. 1991; 7(6): 242-245.
- Deniz-Sungur D, Onur MA, Akbay E i wsp. Effects of calcium silicate cements on neuronal conductivity. Restor Dent Endod. 2022; 47(2): e18.
- Geurtsen W. Biocompatibility of root canal filling materials. Aust Endod J. 2001; 27(1): 12-21.
- Pérez-Serrano RM, Soza-Bolaños AI, Castillo-Valdés SN i wsp. Endodontic set sealer eluates promote cytokine production in human mononuclear and periodontal ligament cells. Aust Endod J. 2021; 47(3): 415-422.
- Swenberg JA, Kerns WD, Mitchell RI i wsp. Induction of squamous cell carcinomas of the rat nasal cavity by inhalation exposure to formaldehyde vapor. Cancer Res. 1980; 40(9): 3398-3402.
- Goldmacher VS, Thilly WG. Formaldehyde is mutagenic for cultured human cells. Mutat Res. 1983; 116(3-4): 417-422.
- Block RM, Lewis RD, Sheats JB i wsp. Antibody formation to dog pulp tissue altered by formocresol within the root canal. Oral Surg Oral Med Oral Pathol. 1978; 45(2): 282-292.
- Broisman H, van Houte J, Krakow AA. Antimicrobial effects of N2 in vitro. Oral Surg Oral Med Oral Pathol. 1978; 45(1): 116-122.
- Tronstad L, Yang ZP, Trope M i wsp. Controlled release of medicaments in endodontic therapy. Endod Dent Traumatol. 1985; 1(4): 130-134.
- Wefelmeier M, Hadrossek PH, Ott KHR. Die Wurzelkanalsealer Endomethasone und Endomethasone N – Eine Literaturübersicht. 2013; 22(3): 267-275.